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When Blood Cells Go Wild

For your body to function properly, itin a single cell in your bone marrow. In
needs a steady supply of oxygenatedpolycythemia vera, researchers have
blood that is supplied by red bloodfound this mutation to be a change in a
cells. These blood cells carry oxygenprotein switch that tells the cells to
from the lungs to different parts of thegrow. Specifically it's a mutation in
body to give you energy and keep thethe protein JAK2 (the JAK2 V617F
skin healthy.mutation)," explained the Mayo Clinic.
But if the bone marrow makes too many"More than 90 percent of patients with
red blood cells, the blood thickens andpolycythemia vera, and about half of
trouble begins. This is calledpatients with other myeloproliferative
polycythemia vera - a blood disorderdisorders, have this mutation. Doctors
that causes many health problems.and researchers don't understand the
"Polycythemia vera - also called primaryfull role of this mutation and its
polycythemia - occurs most often inimplications for treating the disease,"
older adults. It's rare in peopleit added.
younger than 20. Polycythemia veraBut don't feel so bad if you have this
usually develops very slowly. You maycondition since you can live with the
have it for years without noticing anydisease in the absence of complications
signs or symptoms. Often, polycythemialike a stroke, heart attack, an enlarged
vera is found during a blood test donespleen and skin problems.
for some other reason," said the Mayo"Polycythemia vera causes your blood to
Clinic.be thicker than normal, which can slow
In the early stages, the disease has nothe rate of blood flow through your
symptoms. As it progresses, the patientveins and arteries. Increased blood
may have headaches, dizziness, shortnessthickness and decreased blood flow, as
of breath, difficulty breathingwell as abnormalities in your platelets,
especially when lying down, chest pain,increase your risk of blood clots. Blood
numbness and fatigue.clots can cause a stroke, a heart
No one knows why people get polycythemiaattack, or blockage of an artery in your
vera but it appears to be caused by alungs (pulmonary embolism) or in a vein
mutation in red blood cell production.deep within a muscle (deep vein
The mutation is acquired but how thisthrombosis)," warned the Mayo Clinic.
happens is a mystery. What we know ifTreatment is aimed at keeping the red
that the disease is common in olderblood cell level within a tolerable
people, it affects more men than womenrange. This can be done with the use of
and it appears to run in families.drugs, phlebotomy (removing blood) or
"The problem with blood cell productionlow-dose aspirin to decrease clotting
associated with polycythemia vera isand reduce the chance of a stroke or
caused by a change, or mutation, to DNAheart attack.



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